Dr. István Mikola (born September 8, 1947) is a Hungarian physician and politician, who served as Minister of Health in the first cabinet of Viktor Orbán, between 2001 and 2002. He was also Member of Parliament from Fidesz Fejér County Regional List between 2006 and 2011.Mikola was nominated to the position of Deputy Prime Minister during the 2006 parliamentary election.

He was appointed Hungarian Ambassador to the Organisation for Economic Co-operation and Development (OECD), as a result he resigned as MP on February 28, 2011. He was replaced by Gábor Cserna. Mikola became Secretary of State for Security Policy and International Cooperation in the Third Orbán Government on 15 June 2014. Currently he serves as a state secretary at Ministry of Foreign Affairs and Trade.