In 1974-2004, she worked in the diplomatic service for the Ministry of Foreign Affairs of France in several embassies (Italy, United States, and Chad) and with French representations to international organizations (UN, NATO, Western European Union, OSCE).

In 2003, she was appointed as Extraordinary and Plenipotentiary Ambassador of France to Georgia.

In 2004-2005, she served as Minister of Foreign Affairs of Georgia. After the leaving the post, she founded on 11 March 2006 the political party “The Way of Georgia”.

In 2006-2015, she was an Associate Professor of International Relations at the Institute of Political Studies in Paris, France.

From 2010 to December 2015, she led the United Nations Security Council monitoring group on sanctions against Iran.

In 2016, she won her election as an independent Deputy in the Parliament of Georgia.

Since December 2018, she was elected as 5th President of Georgia.